Blar i forfatter "Norreen-Thorsen, Marthe"

Viser treff 1-2 av 2

    • A human adipose tissue cell-type transcriptome atlas 

      Norreen-Thorsen, Marthe; Struck, Eike Christopher; Öling, Sofia Maria; Zwahlen, Martin; Von Feilitzen, Kalle; Odeberg, Jacob; Lindskog, Cecilia; Pontén, Fredrik; Uhlén, Mathias; Dusart, Philip James; Butler, Lynn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-12)
      The importance of defining cell-type-specific genes is well acknowledged. Technological advances facilitate high-resolution sequencing of single cells, but practical challenges remain. Adipose tissue is composed primarily of adipocytes, large buoyant cells requiring extensive, artefact-generating processing for separation and analysis. Thus, adipocyte data are frequently absent from single-cell ...

    • The identification of cell type defining genes across human tissues and the functional study of the endothelial adhesion G protein-coupled receptor L4 

      Norreen-Thorsen, Marthe (Doctoral thesis; Doktorgradsavhandling, 2023-06-30)
      Cell type specific gene expression profiles underlie differences in cell morphology, behaviour, and specialized function. Single cell RNA sequencing can be used to measure gene expression in individual cells, but challenges remain including limited read-depth, artefactual changes due to dissociation from tissue, difficulties in the analysis of fragile or morphologically complex cell types, and bias ...